Synthesis and characterization of some new cyclohexenone compounds derived from chalcones and evaluation of bacterial activity

In this study, some of the ethyl carboxylate cyclohexenone compounds have been prepared which derived from the chalcone were compounds. The chalcone compounds have been prepared by reaction of cyclohexanone with substituted benzaldehyde (1-8) in an base medium, the resulting chalcones reacted with ethyl acetoacetate using (EtOH/DMF) as a solvent produce substituted cyclohexenone (9-16). The prepared compounds were characterized using physical methods, The prepared compounds were characterized using infrared spectroscopy (FT-IR) and 1H-NMR and 13C-NMR for some of them The antibacterial activity were evaluated of some of them.
Keyword: Chalcone, Cyclohexenone, Robinson reaction, ClaisenSchmidt reactions