تحضير وتشخيص بعض المركبات الحلقية غير المتجانسة الجديدة (ثيازوليدين، وتترازول، وأزيتيدينون) من قواعد شيف التي تحتوي على 4،1-ثنائي هيدروبيريدين

القسم: Article
إصدار
مجلد 22 عدد 1 (2026): المجلد (22) العدد (1) لسنة 2026
الصفحات
188-208

الملخص

تتضمن هذه الدراسة تحضير قواعد شيف جديدة ومركبات حلقية غير متجانسة ابتداءآ من 5،3-ثنائي أسيتيل-6،2-ثنائي ميثيل-4،1-ثنائي هيدروبيريدين كمادة أولية. ولتشخيص المركبات المُحضّرة، استخدمت الخصائص الفيزيائية كدرجة الانصهار واللون، بالإضافة الى تقنيات التحليل الطيفي مثل الاشعة تحت الحمراء والرنين النووي المغناطيسي وكروموتوغرافيا الطبقة الرقيقة ونظرًا لأهميتها، تُستخدم هذه المركبات في العديد من المجالات كالصناعات الدوائية والصيدلانية، ولها تأثيرات بيولوجية تشمل مضادات الفطريات والفيروسات والمضادات الحيوية ومضادات السرطان.

الكلمات المفتاحية:

قواعد شف، مركبات حلقية غير متجانسة، ثيازوليدين، وتترازول، وأزيتيدينون

المراجع

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  2. Abid, O. H., & Ahmed, K. R. (2018). Preparation and identification of 1, 3-oxazepine derivatives from selected carboxylic acid anhydrides with imines derived from 4-methyl aniline. Al-Must J Sci, 29(2), 93–100.
  3. Al-Mulla, A. (2017). A review: biological importance of heterocyclic compounds. Der Pharma Chemica, 9(13), 141–147.
  4. Arora, P., Arora, V., Lamba, H. S., & Wadhwa, D. (2012). Importance of heterocyclic chemistry: A review. International Journal of Pharmaceutical Sciences and Research, 3(9), 2947.
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  6. Fayyadh, A., & Al-rawi, M. (2023). Design, Synthesis, and Biological Activity of New Thiazolidine-4- One Derived from Symmetrical 4-Amino-1,2,4-Triazole. Chemical Methodologies, 106–111. https://doi.org/10.22034/CHEMM.2023.362512.1610
  7. González-Andrés, P., Fernández-Peña, L., Díez-Poza, C., Villalobos, C., Nuñez, L., & Barbero, A. (2021). Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches. Marine Drugs, 19(2), 78.
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  11. Kabir, E., & Uzzaman, M. (2022). A review on biological and medicinal impact of heterocyclic compounds. Results in Chemistry, 4, 100606.
  12. Kareem, A. F., Kadhum, S. A., & AlSa’ady, A. T. (2024). Preparation of new mefenamic acid compounds and evaluation the biological activities of their derivatives. Caspian Journal of Environmental Sciences, 22(1), 147–154.
  13. Kidwai, M., Venktaramanan, R., Mohan, R., & Sapra, P. (2002). Cancer chemotherapy and heterocyclic compounds. Current Medicinal Chemistry, 9(12), 1209–1228.
  14. Marín-Ocampo, L., Veloza, L. A., Abonia, R., & Sepúlveda-Arias, J. C. (2019). Anti-inflammatory activity of triazine derivatives: A systematic review. European Journal of Medicinal Chemistry, 162, 435–447.
  15. Muhammed, M. K. (2023). Synthesis, Characterization of Substituted 1, 3-Oxazepine, Thiazolidine-4-one and Azetidine-2-one Using Benzimidazole as a Synthon. Rafidain Journal of Science, 32(1), 110–120.
  16. Nilkanth, P. R., Ghorai, S. K., Sathiyanarayanan, A., Dhawale, K., Ahamad, T., Gawande, M. B., & Shelke, S. N. (2020). Synthesis and Evaluation of Anticonvulsant Activity of Some Schiff Bases of 7‐Amino‐1, 3‐dihydro‐2H‐1, 4‐benzodiazepin‐2‐one. Chemistry & Biodiversity, 17(9), e2000342.
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  20. Shntaif, A. H., & Rashid, Z. M. (2016). The Synthesis of Schiff bases under microwave Irradiation. Journal of Chemical and Pharmaceutical Science, 9(3).
  21. Yahya, Z. K., & Roof, M. Y. (2022). Synthesis of some new Pyrazoline Carbothioamides and Pyrimidinethiols Derivatives from Bis-α, β-Unsaturated Carbonyl Compounds. Rafidain Journal of Science, 31(3), 19–28.
  22. Abdel-Mohsen, H. T., Conrad, J., & Beifuss, U. (2012). Laccase-catalyzed oxidation of Hantzsch 1, 4-dihydropyridines to pyridines and a new one pot synthesis of pyridines. Green Chemistry, 14(10), 2686–2690.
  23. Abid, O. H., & Ahmed, K. R. (2018). Preparation and identification of 1, 3-oxazepine derivatives from selected carboxylic acid anhydrides with imines derived from 4-methyl aniline. Al-Must J Sci, 29(2), 93–100.
  24. Al-Mulla, A. (2017). A review: biological importance of heterocyclic compounds. Der Pharma Chemica, 9(13), 141–147.
  25. Arora, P., Arora, V., Lamba, H. S., & Wadhwa, D. (2012). Importance of heterocyclic chemistry: A review. International Journal of Pharmaceutical Sciences and Research, 3(9), 2947.
  26. Farhan, M. A., Ali, W. B., & Nief, O. A. (2022). Synthesis, Characterization and Biological Activity of Schiff Bases Derived from Heterocyclic Compounds. Synthesis, 45(01).
  27. Fayyadh, A., & Al-rawi, M. (2023). Design, Synthesis, and Biological Activity of New Thiazolidine-4- One Derived from Symmetrical 4-Amino-1,2,4-Triazole. Chemical Methodologies, 106–111. https://doi.org/10.22034/CHEMM.2023.362512.1610
  28. González-Andrés, P., Fernández-Peña, L., Díez-Poza, C., Villalobos, C., Nuñez, L., & Barbero, A. (2021). Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches. Marine Drugs, 19(2), 78.
  29. Habeeb, M. F., & Sheat, A. M. (2023). Studies on Synthesis, Characterization and Biological Activities of Novel Schiff Bases from amino acridone. Egyptian Journal of Chemistry, 66(6), 225–234.
  30. Hassan, T. G., & Omar, A. O. (2023). Synthesis, Characterization of some new Heterocyclic Compounds Derived from Chalcones Containing Schiff Bases. Synthesis, 32(1), 127–137.
  31. Jawad, A. H., Shneine, J. K., Ahmed, A., & Abdulrasool, M. M. (2012). Synthesis, characterization and evaluation of biological activity of some heterocyclic compounds containing 1, 2, 4-triazole ring. Int. J. Research Pharm. Chem, 2, 2231–2781.
  32. Kabir, E., & Uzzaman, M. (2022). A review on biological and medicinal impact of heterocyclic compounds. Results in Chemistry, 4, 100606.
  33. Kareem, A. F., Kadhum, S. A., & AlSa’ady, A. T. (2024). Preparation of new mefenamic acid compounds and evaluation the biological activities of their derivatives. Caspian Journal of Environmental Sciences, 22(1), 147–154.
  34. Kidwai, M., Venktaramanan, R., Mohan, R., & Sapra, P. (2002). Cancer chemotherapy and heterocyclic compounds. Current Medicinal Chemistry, 9(12), 1209–1228.
  35. Marín-Ocampo, L., Veloza, L. A., Abonia, R., & Sepúlveda-Arias, J. C. (2019). Anti-inflammatory activity of triazine derivatives: A systematic review. European Journal of Medicinal Chemistry, 162, 435–447.
  36. Muhammed, M. K. (2023). Synthesis, Characterization of Substituted 1, 3-Oxazepine, Thiazolidine-4-one and Azetidine-2-one Using Benzimidazole as a Synthon. Rafidain Journal of Science, 32(1), 110–120.
  37. Nilkanth, P. R., Ghorai, S. K., Sathiyanarayanan, A., Dhawale, K., Ahamad, T., Gawande, M. B., & Shelke, S. N. (2020). Synthesis and Evaluation of Anticonvulsant Activity of Some Schiff Bases of 7‐Amino‐1, 3‐dihydro‐2H‐1, 4‐benzodiazepin‐2‐one. Chemistry & Biodiversity, 17(9), e2000342.
  38. Peerzada, M. N., Hamel, E., Bai, R., Supuran, C. T., & Azam, A. (2021). Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development. Pharmacology & Therapeutics, 225, 107860.
  39. Qadir, T., Amin, A., Sharma, P. K., Jeelani, I., & Abe, H. (2022). A review on medicinally important heterocyclic compounds. The Open Medicinal Chemistry Journal, 16(1).
  40. Sandhu, Q.-U.-A., Pervaiz, M., Majid, A., Younas, U., Saeed, Z., Ashraf, A., Khan, R. R. M., Ullah, S., Ali, F., & Jelani, S. (2023). Schiff base metal complexes as anti-inflammatory agents. Journal of Coordination Chemistry, 76(9–10), 1094–1118.
  41. Shntaif, A. H., & Rashid, Z. M. (2016). The Synthesis of Schiff bases under microwave Irradiation. Journal of Chemical and Pharmaceutical Science, 9(3).
  42. Yahya, Z. K., & Roof, M. Y. (2022). Synthesis of some new Pyrazoline Carbothioamides and Pyrimidinethiols Derivatives from Bis-α, β-Unsaturated Carbonyl Compounds. Rafidain Journal of Science, 31(3), 19–28.

المؤلفون

ناريمان حميد ابراهيم

جامعة الموصل، كلية العلوم، قسم الكيمياء، الموصل، العراق

منيرة يوسف رؤوف

جامعة الموصل، كلية العلوم، قسم الكيمياء، الموصل، العراق.

المعرفات

معرف الكائن الرقمي DOI: 10.33899/berj.2026.Vol22.Iss1.61913

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طريقة الاقتباس

تحضير وتشخيص بعض المركبات الحلقية غير المتجانسة الجديدة (ثيازوليدين، وتترازول، وأزيتيدينون) من قواعد شيف التي تحتوي على 4،1-ثنائي هيدروبيريدين. (2026). مجلة ابحاث كلية التربية الاساسية, 22(1), 188-208. https://doi.org/10.33899/berj.2026.Vol22.Iss1.61913
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