Preparation of some 1,3,4-oxadiazole and azetidine-2-one derivatives associated with 6-nitro-3-(substituted)-quinoline-4-ol derivatives
Abstract
This research includes preparation of heterocyclic compounds such as 4,3,1-oxadiazole and azetidine-2-one containing the compound 4-hydroxy-6-Nitro-Quinoline. Azetidine compounds (Z12-15) were prepared from treatment of hydrazone with chloroacetic chloride, while oxadiazole compounds were prepared from stirring of hydrazone with concentrated sulfuric acid. Hydrazone compound was prepared from treatment of hydrazide compound with some aromatic aldehydes. Hydrazide compound was prepared by using 4-nitroaniline as a starting material with diethyl ethoxy ethylene malonate to give after heating with diphenyl ether desired Ester compound, which is then treated with aqueous hydrazine.
References
- Anusha, K., Kumar, Y. P., Prasad, M. V., & Gopinath, C. (2015). A review on 2-Azetidinones. Journal of Global Trends in Pharmaceutical Sciences, (6), 2388-2402
- Bordei Telehoiu, A. T., Nuță, D. C., Căproiu, M. T., Dumitrascu, F., Zarafu, I., Ioniță, P., ... & Limban, C. (2020). Design, Synthesis and In Vitro Characterization of Novel Antimicrobial Agents Based on 6-Chloro-9 H-carbazol Derivatives and 1, 3, 4-Oxadiazole Scaffolds. Molecules , 25(2), 266.
- Jones, R. E. (1947). Direct Preparative Methods for Intermediates in the Synthesis of Substituted 4-Haloquinolines. University of Illinois at Urbana-Champaign.Vol.(68), 1204-1208
- Karabelyov, V., Kondeva-Burdina, M., & Angelova, V. T. (2021). Synthetic approaches to unsymmetrical 2, 5-disubstituted 1, 3, 4-oxadiazoles and their MAO-B inhibitory activity. A review. Bioorganic & Medicinal Chemistry, 29, 115888
- Lima, L. M., da Silva, B. N. M., Barbosa, G., & Barreiro, E. J. (2020). β-lactam antibiotics: An overview from a medicinal chemistry perspective. European journal of medicinal chemistry, 208, 112829
- Makhova, N. N., & Fershtat, L. L. (2018). Recent advances in the synthesis and functionalization of 1, 2, 5-oxadiazole 2-oxides. Tetrahedron Letters, 59(24), 2326-2317.
- Marella,A,O,P.Saha .R,Ali .M,R. Srives et al .(2013) . quinoline Aversatile hetrocyclic, Suadi pharmacetical Journal , 2(1) ,1_12.
- Mermer, A., Keles, T., & Sirin, Y. (2021). Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review. Bioorganic Chemistry, 114,105076.
- Sarshira, E. M., Hamada, N. M., Moghazi, Y. M., & Abdelrahman, M. M. (2016). Synthesis and biological evaluation of some heterocyclic compounds from salicylic acid hydrazide. Journal of Heterocyclic Chemistry, 53(6), 1970-1982
- Shabeeb, I., Al-Essa, L., Shtaiwi, M., Al-Shalabi, E., Younes, E., Okasha, R., & Abu Sini, M. (2019). New hydrazide-hydrazone derivatives of quinoline 3-carboxylic acid hydrazide: synthesis, theoretical modeling and antibacterial evaluation. Letters in Organic Chemistry, 16(5), 430-436
- Thomas, A. B., Nanda, R. K., Kothapalli, L. P., & Hamane, S. C. (2016). Synthesis and biological evaluation of Schiff’s bases and 2-azetidinones of isonocotinyl hydrazone as potential antidepressant and nootropic agents. Arabian Journal of Chemistry,( 9), 79-90
- Yaswanth, M., & Deepa, M. (2020). In- silico design, synthesis, characterization and biological evaluation of novel 2-azetidinone derivatives for anti-leukemic activity Journal of Peerscientist, 2(1), e1000009
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