Synthesis and Characterization of Some New Heterocyclic Compounds (Thiazolidine, Tetrazole And Azetidinone) from Schiff Bases Contain 1,4-Dihydropyridine

Section: Article
Issue
Vol. 22 No. 1 (2026): Volume (22) Issue (1) March 2026
Pages
188-208

Abstract

This study involves the synthesis of new Schiff bases and heterocyclic compounds beginning from 3,5-diacetyl-2,6-dimethyl-1,4-dihyropyridine as the starting material. To Characterize the prepared compounds, uses the physical properties such as melting point and color, additionally the spectroscopic techniques FT-IR, 1H-NMR, 13C-NMR, TLC. Given the importance, it is used in many fields such as drugs and pharmaceutical industry and have biological actions including antifungal, antiviral, antibiotics and anticancer.

Keywords:

Schiff bases, heterocyclic compounds, thiazolidine, tetrazole, azetidinone

References

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  2. Abid, O. H., & Ahmed, K. R. (2018). Preparation and identification of 1, 3-oxazepine derivatives from selected carboxylic acid anhydrides with imines derived from 4-methyl aniline. Al-Must J Sci, 29(2), 93–100.
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  13. Kidwai, M., Venktaramanan, R., Mohan, R., & Sapra, P. (2002). Cancer chemotherapy and heterocyclic compounds. Current Medicinal Chemistry, 9(12), 1209–1228.
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  15. Muhammed, M. K. (2023). Synthesis, Characterization of Substituted 1, 3-Oxazepine, Thiazolidine-4-one and Azetidine-2-one Using Benzimidazole as a Synthon. Rafidain Journal of Science, 32(1), 110–120.
  16. Nilkanth, P. R., Ghorai, S. K., Sathiyanarayanan, A., Dhawale, K., Ahamad, T., Gawande, M. B., & Shelke, S. N. (2020). Synthesis and Evaluation of Anticonvulsant Activity of Some Schiff Bases of 7‐Amino‐1, 3‐dihydro‐2H‐1, 4‐benzodiazepin‐2‐one. Chemistry & Biodiversity, 17(9), e2000342.
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  22. Abdel-Mohsen, H. T., Conrad, J., & Beifuss, U. (2012). Laccase-catalyzed oxidation of Hantzsch 1, 4-dihydropyridines to pyridines and a new one pot synthesis of pyridines. Green Chemistry, 14(10), 2686–2690.
  23. Abid, O. H., & Ahmed, K. R. (2018). Preparation and identification of 1, 3-oxazepine derivatives from selected carboxylic acid anhydrides with imines derived from 4-methyl aniline. Al-Must J Sci, 29(2), 93–100.
  24. Al-Mulla, A. (2017). A review: biological importance of heterocyclic compounds. Der Pharma Chemica, 9(13), 141–147.
  25. Arora, P., Arora, V., Lamba, H. S., & Wadhwa, D. (2012). Importance of heterocyclic chemistry: A review. International Journal of Pharmaceutical Sciences and Research, 3(9), 2947.
  26. Farhan, M. A., Ali, W. B., & Nief, O. A. (2022). Synthesis, Characterization and Biological Activity of Schiff Bases Derived from Heterocyclic Compounds. Synthesis, 45(01).
  27. Fayyadh, A., & Al-rawi, M. (2023). Design, Synthesis, and Biological Activity of New Thiazolidine-4- One Derived from Symmetrical 4-Amino-1,2,4-Triazole. Chemical Methodologies, 106–111. https://doi.org/10.22034/CHEMM.2023.362512.1610
  28. González-Andrés, P., Fernández-Peña, L., Díez-Poza, C., Villalobos, C., Nuñez, L., & Barbero, A. (2021). Marine Heterocyclic Compounds That Modulate Intracellular Calcium Signals: Chemistry and Synthesis Approaches. Marine Drugs, 19(2), 78.
  29. Habeeb, M. F., & Sheat, A. M. (2023). Studies on Synthesis, Characterization and Biological Activities of Novel Schiff Bases from amino acridone. Egyptian Journal of Chemistry, 66(6), 225–234.
  30. Hassan, T. G., & Omar, A. O. (2023). Synthesis, Characterization of some new Heterocyclic Compounds Derived from Chalcones Containing Schiff Bases. Synthesis, 32(1), 127–137.
  31. Jawad, A. H., Shneine, J. K., Ahmed, A., & Abdulrasool, M. M. (2012). Synthesis, characterization and evaluation of biological activity of some heterocyclic compounds containing 1, 2, 4-triazole ring. Int. J. Research Pharm. Chem, 2, 2231–2781.
  32. Kabir, E., & Uzzaman, M. (2022). A review on biological and medicinal impact of heterocyclic compounds. Results in Chemistry, 4, 100606.
  33. Kareem, A. F., Kadhum, S. A., & AlSa’ady, A. T. (2024). Preparation of new mefenamic acid compounds and evaluation the biological activities of their derivatives. Caspian Journal of Environmental Sciences, 22(1), 147–154.
  34. Kidwai, M., Venktaramanan, R., Mohan, R., & Sapra, P. (2002). Cancer chemotherapy and heterocyclic compounds. Current Medicinal Chemistry, 9(12), 1209–1228.
  35. Marín-Ocampo, L., Veloza, L. A., Abonia, R., & Sepúlveda-Arias, J. C. (2019). Anti-inflammatory activity of triazine derivatives: A systematic review. European Journal of Medicinal Chemistry, 162, 435–447.
  36. Muhammed, M. K. (2023). Synthesis, Characterization of Substituted 1, 3-Oxazepine, Thiazolidine-4-one and Azetidine-2-one Using Benzimidazole as a Synthon. Rafidain Journal of Science, 32(1), 110–120.
  37. Nilkanth, P. R., Ghorai, S. K., Sathiyanarayanan, A., Dhawale, K., Ahamad, T., Gawande, M. B., & Shelke, S. N. (2020). Synthesis and Evaluation of Anticonvulsant Activity of Some Schiff Bases of 7‐Amino‐1, 3‐dihydro‐2H‐1, 4‐benzodiazepin‐2‐one. Chemistry & Biodiversity, 17(9), e2000342.
  38. Peerzada, M. N., Hamel, E., Bai, R., Supuran, C. T., & Azam, A. (2021). Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development. Pharmacology & Therapeutics, 225, 107860.
  39. Qadir, T., Amin, A., Sharma, P. K., Jeelani, I., & Abe, H. (2022). A review on medicinally important heterocyclic compounds. The Open Medicinal Chemistry Journal, 16(1).
  40. Sandhu, Q.-U.-A., Pervaiz, M., Majid, A., Younas, U., Saeed, Z., Ashraf, A., Khan, R. R. M., Ullah, S., Ali, F., & Jelani, S. (2023). Schiff base metal complexes as anti-inflammatory agents. Journal of Coordination Chemistry, 76(9–10), 1094–1118.
  41. Shntaif, A. H., & Rashid, Z. M. (2016). The Synthesis of Schiff bases under microwave Irradiation. Journal of Chemical and Pharmaceutical Science, 9(3).
  42. Yahya, Z. K., & Roof, M. Y. (2022). Synthesis of some new Pyrazoline Carbothioamides and Pyrimidinethiols Derivatives from Bis-α, β-Unsaturated Carbonyl Compounds. Rafidain Journal of Science, 31(3), 19–28.

Authors

Nariman H. Ibrahim

Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.

Muneera Y. Raoof

Department of Chemistry, College of Science, University of Mosul, Mosul, Iraq.

Identifiers

DOI: 10.33899/berj.2026.Vol22.Iss1.61913

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Synthesis and Characterization of Some New Heterocyclic Compounds (Thiazolidine, Tetrazole And Azetidinone) from Schiff Bases Contain 1,4-Dihydropyridine. (2026). College of Basic Education Research Journal, 22(1), 188-208. https://doi.org/10.33899/berj.2026.Vol22.Iss1.61913
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How to Cite

Synthesis and Characterization of Some New Heterocyclic Compounds (Thiazolidine, Tetrazole And Azetidinone) from Schiff Bases Contain 1,4-Dihydropyridine. (2026). College of Basic Education Research Journal, 22(1), 188-208. https://doi.org/10.33899/berj.2026.Vol22.Iss1.61913